Behavioral effects of lesions to the caudate nucleus or mediodorsal thalamus in neonatal, juvenile, and adult rats
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چکیده
منابع مشابه
The effects of lesions to the postsubiculum or the anterior dorsal nucleus of the thalamus on spatial learning in rats.
To investigate the role of the head direction (HD) cell circuit in spatial navigation, rats with bilateral, neurotoxic lesions to the postsubiculum (PoS; Experiment 1) or the anterior dorsal nucleus of the thalamus (ADN; Experiment 2) were compared to sham controls on 2 tasks that could be solved using directional heading. Rats were first trained on a direction problem in a water T maze where t...
متن کاملBehavioral and cognitive changes after early postnatal lesions of the rat mediodorsal thalamus
Early insults to the thalamus result in functional and/or structural abnormalities in the cerebral cortex. However, differences in behavioral and cognitive changes after early insult are not well characterized. The present study assessed whether early postnatal damage to mediodorsal nucleus of the thalamus (MD), reciprocally interconnected with the prefrontal cortex, causes behavioral and cogni...
متن کاملStatus epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats.
Status epilepticus (StE) in immature rats causes long-term functional impairment. Whether this is associated with structural alterations remains controversial. The present study was designed to test the hypothesis that StE at an early age results in neuronal loss. StE was induced with lithium-pilocarpine in 12-d-old rats, and the presence of neuronal damage was investigated in the brain from 12...
متن کاملDissociative effects of selective lesions in the caudate nucleus of cats and rats.
Lesions in the neostriatal region connected to the prefrontal cortex severely impaired delayed alternation in both cats and rats, whereas no such effect was found after damage to other neostriatal regions. These results indicate that the processes mediating delayed alternation are well localized in the neostriatum of both cats and rats. Two possible models of neostriatal functioning are discuss...
متن کاملNeurotoxic lesions of the medial mediodorsal nucleus of the thalamus disrupt reinforcer devaluation effects in rhesus monkeys.
The mediodorsal thalamus is a major input to the prefrontal cortex and is thought to modulate cognitive functions of the prefrontal cortex. Damage to the medial, magnocellular part of the mediodorsal thalamus (MDmc) impairs cognitive functions dependent on prefrontal cortex, including memory. The contribution of MDmc to other aspects of cognition dependent on prefrontal cortex has not been dete...
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ژورنال
عنوان ژورنال: Physiological Psychology
سال: 1982
ISSN: 0090-5046
DOI: 10.3758/bf03332944